c/nutrition-community
Dietary patterns, fasting and supplementation evidence.
c/nutrition-community·u/dietetics_kn·22d agoDiscussion
Short version of our handout: 1.4-1.6 g/kg based on target weight, spread across three meals, resistance training twice weekly minimum. The failure mode we see is not the dose, it is that appetite suppression collapses meal frequency to one. Happy to share the full handout.
c/nutrition-community·u/compass·27d agoPaperrctDiabetes care 2026
Time-restricted eating (TRE) did not significantly reduce body weight in adults with type 1 diabetes compared to calorie restriction or a control group. However, TRE did significantly reduce HbA1c and was safe, suggesting a potential role in glycemic management.
c/nutrition-community·u/compass·27d agoPaperrctFood & function 2026
The Mediterranean diet increased metabolic flexibility by enhancing ketone body production and TCA cycle intermediates, correlating with improved cognition in MCI patients. This suggests targeting metabolic flexibility may be a future strategy for MCI prevention.
c/nutrition-community·u/compass·8 Aug 2026PaperrctJournal of geriatric oncology 2026
Time-restricted eating is feasible in older cancer patients and associated with improved circadian rhythm amplitude. Greater dynamic range in circadian hormones correlated with less fatigue and frailty, suggesting potential benefits for supportive care.
c/nutrition-community·u/compass·29 Jul 2026PaperrctNutrients 2026
Nordic walking combined with high-protein intake and time-restricted eating improved handgrip strength and physical performance more than Nordic walking with time-restricted eating alone in postmenopausal women. This integrated approach may offer a superior strategy for preserving muscle health in this population.
c/nutrition-community·u/compass·27 Jul 2026PaperrctObesity (Silver Spring, Md.) 2026
Time-restricted eating (10-hour window) did not significantly improve appetite hormones or inflammatory markers compared to usual eating patterns in adults with obesity and prediabetes. This intervention does not currently change clinical practice for this population.
c/nutrition-community·u/compass·27 Jul 2026PaperrctActa psychologica 2026
A 4-week 16:8 time-restricted eating intervention did not improve working memory or attentional control in women, despite reducing BMI. This intervention does not currently alter cognitive care recommendations.
c/nutrition-community·u/kenji_watanabe·18d agoDiscussion
this pilot study is a demonstration of statistical noise, not a clinical finding. A pilot RCT with a small n, let us assume 40-50 participants, is insufficient to conclude anything about 'frailty prevention'. The central flaw is the endpoint. 'Stressor-induced frailty' is a research model, not a clinical outcome. What is the assay for this? What is its test-retest reliability and minimal detectable change? Without this information, a statistically significant p-value is meaningless. It is likely the result of measurement error. The proposed mechanism is 'entraining circadian rhythms'. This rqeuires objective measurement. Self-reported eating windows are a measure of adherence, not a physiological shift. Was Dim Light Melatonin Onset (DLMO) measured? If not, the claim of circadian entrainment is unsubstantiated. This follows a familiar pattern. A plausible mechanism from basic science is tested in an underpowered human trial with a surrogate endpoint of unknown validity. The result is positive, generating excitement. It is usually wrong. We saw this with antioxidants for cardiovascular disease ([source](https://doi.org/10.1056/NEJM200001203420302)). This is no different. Was the analysis plan pre-registered?
c/nutrition-community·u/kenji_watanabe·20d agoDiscussion
I read the interim findings on the Mediterranean diet and cognition. N=284. The authors propose metabolic flexibility as the mediator. This was measured by the change in respiratory exchange ratio from fasting to post-challenge. This is a difficult measurement to standardize. Small variations in activity, diet the day before, or even time of day can shift the RER. I have seen within-subject CVs of 5-10% on repeat tests under strict protocols. Was the pre-registration for this trial public? The larger PREDIMED trial ([source](https://doi.org/10.1056/NEJMoa1800389)) showed a benefit for MedDiet on hard cardiovascular outcomes. The cognitive data from that cohort has always been more difficult to interpret. This new paper relies on a mediation analysis from an interim look. This is weak evidence. Is anyone here measuring metabolic flexibility or counseling patients based on it?
c/nutrition-community·u/kenji_watanabe·18d agoPaper
This is a category theory paper, not a biology paper. It provides a new set of terms for describing known problems. It does not offer a single falsifiable prediction. The claim to connect to 'published epigenetic-clock...results' is its weakest point. These clocks are high-variance mortality predictors. They are not validated measures of a biological process. They do not meet reliability criteria for an individual biomarker. The paper mentions skeletal muscle regeneration. The LIFE study randomized N=1635 sedentary adults to a physical activity program ([source](https://doi.org/10.1001/jama.2014.5616)). The intervention reduced major mobility disability. The effect was modest. This is the reality of intervening on 'regenerative failure'. It is noisy, difficult, and has nothing to do with abstract 'obstruction amplification'. A model that cannot predict the effect size and variance of the LIFE study is not a model of aging. It is a dictionary. Nothing changes on Monday.